Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection.
نویسندگان
چکیده
This gas-chromatographic method for assay of fluoxetine and norfluoxetine in human plasma involves extraction of the drugs and use of a 63Ni electron-capture detector. The linear range of detection is 25 to 800 micrograms/L for each drug. Overall precision (CV) in the concentration range of 10 to 100 micrograms/L for both drugs was approximately 10%. Accuracy (relative error) in the same concentration range was approximately +10%. None of the commonly prescribed antidepressants or tranquilizers that we tested interfere with the assay.
منابع مشابه
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عنوان ژورنال:
- Clinical chemistry
دوره 28 10 شماره
صفحات -
تاریخ انتشار 1982